What is a stimulus triggered activation of pluripotency STAP stem cell?
STAP (stimulus-triggered acquisition of pluripotency) cells were thought to be engineered stem cells created when hematopoietic stem cells from the spleens of newborn mice were exposed to an acid environment, triggering their conversion from multipotent somatic cells to pluripotent-like stem cells.
How Japanese stem cell study became a scandal?
Its findings concluded that there was “research misconduct by Dr Obokata on two points”. She was found to have manipulated two images to create a false composite image, and she used data from her doctoral thesis, even though it was derived under different conditions to those described in her STAP papers.
Are STAP cells real?
In one critical experiment where STAP-derived cells were reported to behave like both embryonic and placental stem cells, it was found that the cell populations were in fact a mixture of embryonic and placental stem cells that pre-existed in the lab.
What happened with STAP cell research?
On 24 September 2015, the RIKEN scientists reported that Obokata’s STAP cells came from embryonic stem cell contamination, while on the same day, research groups who had attempted to reproduce the STAP protocol jointly reported that they had found it irreproducible.
Did Dr Obokata Act represent misconduct?
A young researcher who shot to fame in scientific circles when she published an apparently radical and simple way to create stem cells has been found guilty of misconduct by a committee charged with investigating her work.
Do STAP cells exist?
How are stem cells induced?
Induced stem cells (iSC) are stem cells derived from somatic, reproductive, pluripotent or other cell types by deliberate epigenetic reprogramming.
How do you induce pluripotency?
The four classical transcription factors that have been demonstrated to induce pluripotency are Oct4, Sox2, cMyc, and Klf4. These factors are also known as Yamanaka factors, after the researcher who discovered their reprogramming effects. Multiple methods can be used to induce expression of these transcription factors.