Which of the following is the most common cause of hyperviscosity syndrome?

Which of the following is the most common cause of hyperviscosity syndrome?

Waldenström’s macroglobulinaemia (WB). This is the most common cause of hyperviscosity syndrome; around 10-30% of patients who are diagnosed with hyperviscosity have WB. WB is a blood cancer that occurs within the bone marrow and the lymphatic tissues.

What are Hyperviscosity syndromes?

Hyperviscosity syndrome (HVS) refers to the clinical sequelae of increased blood viscosity. Increased serum viscosity usually results from increased circulating serum immunoglobulins and can be seen in such diseases as Waldenström macroglobulinemia and multiple myeloma.

How is hyperviscosity syndrome diagnosed?

The diagnosis of hyperviscosity syndrome (HVS) is confirmed by measurement of elevated serum viscosity in a patient with characteristic clinical manifestations of HVS. No exact diagnostic cut-off exists for serum viscosity, as different patients will have symptoms at different values.

What level of IgM causes hyperviscosity?

IgM is pentameric and very large in size (970 kDA), and serum viscosity can increase significantly with IgM levels as low as 3 g/dL, and IgM levels of 6 g/dL or higher are associated with rapid development of hyperviscosity, with a median time to symptomatic HVS of 3 months (9, 10).

What is a complication of hyperviscosity syndrome?

Complications may occur if the condition is more severe or if your baby isn’t responding to treatment. These complications can include: stroke. kidney failure.

How is hyperviscosity syndrome treated?

Plasmapheresis is the treatment of choice for initial management and stabilization of hyperviscosity syndrome (HVS) caused by the paraproteinemias (the majority of cases). Plasmapheresis is usually well tolerated and safe.

Is hyperviscosity syndrome curable?

Does polycythemia cause hyperviscosity?

Polycythemia is an abnormal increase in red blood cell mass, defined in neonates as a venous hematocrit ≥ 65%; this increase can lead to hyperviscosity with sludging of blood within vessels and sometimes thrombosis.