What is T dependent antigen?
Thymus-dependent antigens include proteins, polypeptides, hapten-carrier complexes, erythrocytes, and many other antigens that have diverse epitopes. T dependent antigens contain some epitopes that T cells recognize and others that B cells identify.
What is T dependent and T-independent antigen?
T-dependent antigens can stimulate B cells to become activated but require cytokine assistance delivered by helper T cells. T-independent antigens can stimulate B cells to become activated and secrete antibodies without assistance from helper T cells.
What is T cell independent antigen?
Antigens are classified as T cell dependent or T cell independent, according to the requirement of T cell involvement in the mounting of an antibody response. T-independent antigens are typically polysaccharides that cannot be presented via MHC molecules.
What are TI and TD antigens?
The B-cell response to thymus-dependent (TD) antigens requires direct contact with TH cells, not simply exposure to TH-derived cytokines. Antigens that can activate B cells in the absence of this kind of direct participation by TH cells are known as thymus-independent (TI) antigens.
What kind of configuration are T-independent antigens?
Abstract. T cell independent antigens do not require T cell help to induce an immune response, and are characterized by a lack of immunologic memory. These antigens can be divided into two classes, TI-1 or TI-2.
Where does antigen independent differentiation of T lymphocytes occur?
T-cell differentiation occurs within the thymus and is characterized by ordered expression of various CD surface molecules and V, D, and J gene rearrangements. Progenitor cells originating in the bone marrow migrate to the thymus.
How are T-dependent antigens different from T-independent antigens quizlet?
How do T-independent antigens differ from T-dependent antigens? T-independent antigens (lipopolysaccharide and polysaccharides that have numerous identical epitopes) can activate B cells in the absence of T-cell assistance, while T-dependent antigens (proteins) require this T-cell assistance).
How are T dependent and T independent antigens different in terms of their immune response quizlet?
What is the difference between NK cells and cytotoxic T cells?
NK cells were first noticed for their ability to kill tumour cells without any priming or prior activation (in contrast to cytotoxic T cells, which need priming by antigen presenting cells). They are named for this ‘natural’ killing.
How can you differentiate a dependent from T-independent antigens quizlet?
T-dependent antigen one requiring the presence of helper cells to stimulate antibody production by B cells. T-independent antigen one able to trigger B cells to produce antibodies without the presence of T cells.