Can lymphocytes have nucleoli?
Reactive Lymphocytes and Blast-Transformed Lymphocytes In contrast, blast-transformed lymphocytes have a large nucleus with a light, dispersed chromatin pattern with prominent nucleoli or nucleolar rings.
Do reactive lymphocytes have nucleoli?
Reactive lymphocytes are heterogeneous – they vary in size and morphologic features (nuclear shape, amount and color of cytoplasm). They all have relatively mature clumped nuclear chromatin and no visible nucleoli. Their nuclear shapes vary quite markedly.
Does lymphocyte have nucleus?
The lymphocyte is an agranular cell with very clear cytoplasm which stains pale blue. Its nucleus is very large for the size of the cell and stains dark purple. (Notice that the nucleus almost fills the cell leaving a very thin rim of cytoplasm.)
Do atypical lymphocytes have nucleoli?
These WBC’s are “atypical” because they are larger (more cytoplasm) and have nucleoli in their nuclei. The cytoplasm tends to be indented by surrounding RBC’s. Such atypical lymphocytes are often associated with infectious mononucleosis from Epstein-Barr virus (EBV) infection.
Where are lymphocytes activated?
The secondary lymphoid organs are sites where naïve lymphocytes are activated, and include lymph nodes, spleen and mucosal-associated lymphoid tissue, such as Peyer’s patches in the small intestine.
What is the difference between atypical and reactive lymphocytes?
Reactive, or atypical, lymphocytes are relatively fragile cells, and as a result can be squeezed out of shape by surrounding cells, giving them a scalloped appearance instead of a smooth cytoplasmic edge. The nucleus of the reactive lymphocyte is larger than that of the small lymphocyte, and is more irregular in shape.
What do smudge cells indicate?
Smudge cells are ruptured chronic lymphocytic leukemia (CLL) cells appearing on the blood smears of CLL patients.
What is lymphoblast and fibroblast?
Lymphoblast Cell Culture Lymphoblasts are immortalized cells, unlike fibroblast cells, which have a finite life span as reflected by the limited passage number. Moreover, blood drawing required for lymphoblast culture is less traumatic than skin biopsies needed for fibroblast culture.
What is the difference between lymphocytes and lymphoblasts?
A lymphocyte that has gotten larger after being stimulated by an antigen. Lymphoblast also refers to an immature cell that can develop into a mature lymphocyte.
Where are lymphocytes stored?
Lymph nodes are small, bean-shaped masses of lymphatic tissue along lymph vessels. They store lymphocytes and filter waste, bacteria and damaged cells (including cancer cells) from lymph. The lymphocytes inside the lymph nodes also attack bacteria and viruses that they find in the lymph.