What is locoregional therapy for breast cancer?
Surgical care is one of the primary treatment modalities for locoregional breast cancer; radiotherapy and systemic therapy are the other primary modalities. Surgical care for breast can- cer requires expert surgical training and coordination of care.
What is locoregional tumor?
Locoregional tumor failure was defined as recurrent or persistent disease involving the ipsilateral lung, hilum, or mediastinum. Radiology reports and radiology examinations including CT and/or PET/CT were reviewed to determine LRF.
What is the pathophysiology of breast cancer?
Breast cancer develops due to DNA damage and genetic mutations that can be influenced by exposure to estrogen. Sometimes there will be an inheritance of DNA defects or pro-cancerous genes like BRCA1 and BRCA2. Thus the family history of ovarian or breast cancer increases the risk for breast cancer development.
How are most breast cancers treated?
Most women with breast cancer in stages I, II, or III are treated with surgery, often followed by radiation therapy. Many women also get some kind of systemic drug therapy (medicine that travels to almost all areas of the body). In general, the more the breast cancer has spread, the more treatment you will likely need.
What is locoregional therapy?
Locoregional therapies, defined as imaging-guided liver tumour-directed procedures, play a leading part in the management of 50–60% of HCCs. Radiofrequency is the mainstay for local ablation at early stages and transarterial chemoembolization (TACE) remains the standard treatment for intermediate-stage HCC.
What does locoregional disease mean?
Locoregional recurrence refers to the recurrence of cancer cells at the same site as the original (primary) tumour or the regional lymph nodes after a disease free period.
Why is chemo given before surgery?
Chemotherapy is sometimes given before surgery (known as neoadjuvant therapy or preoperative chemotherapy) to shrink larger cancers. This may: Allow the surgeon the best chance of removing the cancer completely. Enable the surgeon to remove only the cancer, rather than the entire breast.
What are the types of locoregional therapy?
JFG There are 2 major types of locoregional therapy used in hepatocellular carcinoma (HCC): percutaneous ablation (either chemical or thermal) and intraarterial chemoembolotherapy.
How are isolated locoregional recurrences (ilrrs) treated in breast cancer?
Advances in the treatment of breast cancer have decreased the rate of isolated locoregional recurrences (ILRRs) over time. Surgery, radiation therapy, and systemic therapies are used to manage these failure events and their associated poor prognosis.
Is locoregional control of breast cancer improving after mastectomy?
Locoregional control of breast cancer has improved in both mastectomy- and lumpectomy-treated populations, resulting in fewer locoregional recurrences. Management should be largely individualized and tailored to the extent of disease, the molecular profile of the recurrence, and prior adjuvant treatments.
How are patients with breast cancer randomly assigned for treatment?
Eligible patients were randomly assigned (1:1) to receive locoregional treatment directed at their primary breast tumour and axillary lymph nodes, or no locoregional treatment, with a computer-generated randomisation sequence and a telephone call to the central research office. RH generated the random sequence.
What are the locoregional outcomes of breast-conserving therapy for triple-negative breast cancer?
Zumsteg ZS, Morrow M, Arnold B, et al. Breast-conserving therapy achieves locoregional outcomes comparable to mastectomy in women with T1-2N0 triple-negative breast cancer. Ann Surg Oncol. 2013;20:3469-76.