What are orphan nuclear receptors?

What are orphan nuclear receptors?

Orphan nuclear receptors belong to a superfamily of nuclear receptors, which include the steroid hormone receptors. These nuclear receptors act as ligand-activated transcription factors and they control diverse functions in the cell including lipid metabolism and xenobiotic metabolism.

What is the function of the orphan receptors CAR and PXR?

The orphan NRs CAR and PXR (and its human homolog SXR, steroid and xenobiotic receptor) function as xenobiotic sensors and regulate the expression of various Phase I and II drug-metabolizing enzymes as well as drug-transporter proteins, in response to xenobiotics. Valerie A. Arboleda,

What is the function of the orphan nuclear receptor DAX-1?

The orphan nuclear receptor Dax-1 (Nr0b1) was first cloned as the gene responsible for X-linked cytomegalic adrenal hypoplasia congenita. Its expression in the adrenal gland is enriched in the subcapsular region, suggesting a potential function of Dax-1 in adrenal maintenance.