What is Sp1 gene?

SP1 (Sp1 Transcription Factor) is a Protein Coding gene. Diseases associated with SP1 include Erythroleukemia and Embryonal Carcinoma. Among its related pathways are CNTF Signaling and Cell cycle Cell cycle (generic schema).

Is Sp1 a transcription factor?

Sp1 (specificity protein 1) is a well-known member of a family of transcription factors that also includes Sp2, Sp3 and Sp4, which are implicated in an ample variety of essential biological processes and have been proven important in cell growth, differentiation, apoptosis and carcinogenesis.

What is Sp1 biology?

Sp1 is a ubiquitously expressed, prototypic C2H2-type zinc finger-containing DNA binding protein that can activate or repress transcription in response to physiologic and pathological stimuli.

What does C Jun stand for?

c-Jun is a protein that in humans is encoded by the JUN gene. c-Jun, in combination with c-Fos, forms the AP-1 early response transcription factor. It was first identified as the Fos-binding protein p39 and only later rediscovered as the product of the JUN gene.

What is the role of transcription factor Sp1 in the different cells?

Sp1 was the first characterized and still is one of the best studied mammalian transcription factors. It functions as a transcriptional activator of a variety of genes including house-keeping genes, cell cycle regulators and tissue-restricted genes.

What is the role of Sp1?

Sp1 and Sp3 are transcription factors expressed in all mammalian cells. These factors are involved in regulating the transcriptional activity of genes implicated in most cellular processes.

What is the position of the Sp1 binding site?

Sp1 binds to the GC box motif at nucleotide positions −81/−69 of the β1,4GalT V promoter and play an essential role in promoter activity in cancer cells (Sato and Furukawa, 2004).

What is SP3 in biology?

Sp3 transcription factor, also known as SP3, refers to both a protein and the gene it is encoded by. This gene belongs to a family of Sp1 related genes that encode transcription factors that regulate transcription by binding to consensus GC- and GT-box regulatory elements in target genes.

What does C-FOS stand for?

C-fos is a proto-oncogene that is expressed within some neurons following depolarization. The protein product, c-fos protein, can be identified by immunohistochemical techniques. Therefore, c-fos expression might be used as a marker for neuronal activity throughout the neuraxis following peripheral stimulation.

Is GC box present in prokaryotes?

In molecular biology, a GC box, also known as a GSG box, is a distinct pattern of nucleotides found in the promoter region of some eukaryotic genes. The GC box is upstream of the TATA box and approximately 110 bases upstream from the transcription initiation site.

What is the SP1 gene?

SP1 (Sp1 Transcription Factor) is a Protein Coding gene. Diseases associated with SP1 include Cytomegalovirus Infection and Huntington Disease. Among its related pathways are Gastric cancer and IL4-mediated signaling events.

What is GeneCards®?

GeneCards®: The Human Gene Database GeneCards is a searchable, integrative database that provides comprehensive, user-friendly information on all annotated and predicted human genes.

How many transcript variants are there for the SP1 gene?

Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2014] SP1 (Sp1 Transcription Factor) is a Protein Coding gene. Diseases associated with SP1 include Embryonal Carcinoma and Diabetic Cataract .

What is the pathophysiology of SP1 diabetes?

Diseases associated with SP1 include Embryonal Carcinoma and Diabetic Cataract . Among its related pathways are fMLP Pathway and Regulation of cholesterol biosynthesis by SREBP (SREBF) .

What is SP1 gene?

SP1 (Sp1 Transcription Factor) is a Protein Coding gene. Diseases associated with SP1 include Erythroleukemia and Embryonal Carcinoma. Among its related pathways are Estrogen signaling pathway and Initiation of transcription and translation elongation at the HIV-1 LTR.

Is SP1 a general transcription factor?

Specificity protein 1 (Sp1) is an important transcription factor implicated in numerous cellular processes. However, whether Sp1 is involved in the regulation of RNA polymerase III (Pol III)-directed gene transcription in human cells remains unknown.

What type of transcription factor is Sp1?

Is GC box conserved?

We also show that the CCAAT box and the downstream GC box Sp B, which are conserved between the human and mouse promoters, behave as positive regulatory elements in the mouse TbetaR-II promoter.

Where are SP1 parts stocked?

SP1 products are stocked in 6 strategically placed warehouses across the US, totaling over 1 million square feet of warehouse space. We order deep, and many months ahead of the snow season to have the parts you need, in stock for your dealer.

What is the S&P 500 1 year return?

The S&P 500 1 Year Return is the investment return received for a 1 year period, excluding dividends, when holding the S&P 500 index. The S&P 500 index is a basket of 500 large US stocks, weighted by market cap, and is the most widely followed index representing the US stock market.

Why choose SP1 for OEM parts?

It is common when OEM parts are on backorder for dealers to turn to SP1 for the parts you need. SP1 products are stocked in 6 strategically placed warehouses across the US, totaling over 1 million square feet of warehouse space. We order deep, and many months ahead of the snow season to have the parts you need, in stock for your dealer.

How are SP1 products tested before shipment?

All SP1 products are tested before shipment to maintain the high level of quality that snowmobilers worldwide demand, and most of the factories we use are ISO certified. Product specific testing includes electrical testing reports, 100% testing on cylinders, 3D scanning and constant material analysis on pistons.