Which drugs are MAOI?

MAOIs approved to treat depression

Isocarboxazid (Marplan)
Phenelzine (Nardil)
Selegiline (Emsam)
Tranylcypromine (Parnate)

Which is a selective MAO-B inhibitors?

The amines dopamine (DA) and tyramine show similar affinity for each enzyme form. Clorgyline is a selective inhibitor of MAO-A while selegiline (l-deprenyl) and rasagiline are relatively selective inhibitors of MAO-B.

What is a MAO-B inhibitor?

Monoamine Oxidase Type B (MAO-B) is an enzyme in our body that breaks down several chemicals in the brain, including dopamine. By giving a medication that blocks the effect of MAO-B, an MAO-B inhibitor), more dopamine is available to be used by the brain.

What is the difference between MAO A and MAO-B?

Differences between MAOA and MAOB Monoamine oxidase A (MAOA) generally metabolizes tyramine, norepinephrine (NE), serotonin (5-HT), and dopamine (DA) (and other less clinically relevant chemicals). In contrast, monoamine oxidase B (MAOB) mainly metabolizes dopamine (DA) (and other less clinically relevant chemicals).

Is omeprazole a MAO inhibitor?

The S-enantiomer of omeprazole, esomeprazole, has recently also been described as an inhibitor of monoamine oxidase-A (MAO-A), the main enzyme responsible for 5-HT degradation, albeit with lower potency compared to the effect on TPH1 and TPH2.

Is selegiline MAO-A or B?

Selegiline (L-deprenyl) is a selective, irreversible inhibitor of monoamine oxidase B (MAO-B) at the conventional dose (10 mg/day oral) that is used in the treatment of Parkinson’s disease.

Is carbidopa a MAO-B inhibitor?

MAO-B (monoamine oxidase-B) inhibitors are a class of drugs used to treat the symptoms of Parkinson’s disease (PD). Carbidopa-levodopa therapy is the most effective drug available to treat the motor symptoms of PD. However, other drugs like MAO-B inhibitors may also be used to manage symptoms.

Does MAO-A break down dopamine?

Serotonin, melatonin, norepinephrine, and epinephrine are mainly broken down by MAO-A. Phenethylamine and benzylamine are mainly broken down by MAO-B. Both forms break down dopamine, tyramine, and tryptamine equally.

Is Wellbutrin a MAO inhibitor?

Compared to classical tricyclic antidepressants, Bupropion is a relatively weak inhibitor of the neuronal uptake of norepinephrine and dopamine. In addition, Bupropion does not inhibit monoamine oxidase.

Is Lexapro a MAO inhibitor?

Lexapro is not considered a monoamine oxidase inhibitor (MAOI). MAOIs work by slowing down the breakdown of serotonin and dopamine, another chemical in your brain. This also helps alleviate symptoms of depression. However, MAOIs have a higher risk of side effects and drug interactions than SSRIs such as Lexapro.