How do you calculate wet granulation endpoint?

How do you calculate wet granulation endpoint?

The strength of granules was also inversely related to the intragranular porosity. End Point in a wet granulation process is characterized by rheological properties of the wet mass such as density, viscosity etc which are in turn a function of particle size, shape and other physical properties.

How do you do wet granulation?

Wet granulation method of tablet production involves the following processing steps:

1. Step 1: Weighing and mixing of formulation ingredients (excluding the lubricant).
2. Step 2: Preparing the damp mass.
3. Step 3: Wet screening/ Screening the dampened powder into pellets or granules.
4. Step 4: Drying of moist granules.

How are granules formulated?

√ The granules are formed by the following methods: solid bridges, sintering, chemical reaction, crystallization, and deposition of colloidal particles. √ Granules are formed from the powder particles by wetting and nucleation, coalescence or growth, consolidation, and attrition or breakage.

What is wet granulation used for?

Wet granulation is a widely used process in the pharmaceutical industry since this improves the flow properties, homogeneity and compressibility of the powder mix. Fluidized bed granulators and high shear mixers are typically used in traditional batch wet granulation processes.

What is torque value in RMG?

A torque rheometer provides an off-line measurement of torque required to rotate the blades of the device and can be used to assess rheological properties of the granulation. It has been extensively used for endpoint determination. The torque values obtained have been termed a “measure of wet mass consistency”

Which mixture is used during wet granulation process?

Wet granulation involves the massing of a mix of dry primary powder particles using a granulating fluid. The fluid contains a solvent which can be removed by drying, and should be non-toxic. Typical solvents include water, ethanol and isopropanol and methylene chloride either alone or in combination.

What is milling in wet granulation?

Wet conditioning is conducted before the fluid bed dryer (FBD) process, whereby the wet granulate is passed through a mill in order to provide a uniform granule for drying. After the FBD the dried material is milled again to achieve the particle size as stipulated for the manufacturing process.

What are granulating agents?

A granulating agent provided proper moisture to convert fine powder into damp mass ,which after passing through a sieve of suitable number forms granules. The various granulating agents used are water,alcohol,mucilage of starch,mucilage of acacia ,mucilage of tragacanth,gelatin solution,iso-propyl alcohol,acetone etc.

How are effervescent granules prepared?

Effervescent granules are prepared by Wet method, Fusion method or dry method, hot melt Extrusion method, in which the Fusion method is the most important method for the formulation of Effervescent granules.

Which is better dry or wet granulation?

Importance. Dry Granulation: Dry granulation is required when producing tablets from highly moisture and heat sensitive compounds. Wet Granulation: Wet granulation is required to avoid the destruction of active components in the powder.

Is mannitol use in wet granulation?

The success of a wet granulation process depends on the use of an excipient with excellent binding and compaction properties. Mannitol is frequently used for this purpose in solid dosage formulations owing to its physicochemical properties; it is chemically inert and has good compactibility and low hygroscopicity.