What is klucel?
Klucel™ hydroxypropylcellulose (HPC) is a nonionic water-soluble cellulose ether with a remarkable combination of properties.
What is Klucel EF?
Klucel™ EF Hydroxypropylcellulose is a nonionic polymer that is completely soluble in both water and polar organic solvents like ethanol. This grade has a viscosity of 200-600.
How do you dissolve klucel?
Slowly sprinkle the Klucel G powder in to the alcohol and stir or shake to mix. The mixture will appear clumpy and thick at first but allow at least 24 hours for the material to completely dissolve.
What are the side effects of hydroxypropyl cellulose?
Side Effects
- Blurred vision.
- eye redness or discomfort or other irritation not present before use of this medicine.
- increased sensitivity of eyes to light.
- matting or stickiness of eyelashes.
- swelling of eyelids.
- watering of eyes.
What is hydroxypropyl cellulose good for?
It is used to treat syndromes characterized by insufficient tear production (keratoconjunctivitis sicca), recurrent corneal erosions, decreased corneal sensitivity, exposure and neuroparalytic keratitis, and as a lubricant for artificial eyes.
Is HPC water soluble?
Because of the high levels of hydroxypropylation (~ 70%), HPC is more plastic and relatively hydrophobic as compared to other water-soluble cellulose ethers. It is fully soluble in water and polar organic solvents, such as methanol, ethanol, isopropyl alcohol (IPA), and acetone.
Is hydroxypropyl cellulose harmful?
It is now an EU and FDA-approved food additive and is considered non-toxic to humans.
Is hydroxypropyl methylcellulose low Fodmap?
Hydroxypropyl Methylcellulose has not been tested for FODMAPs. However, Hydroxypropyl Methylcellulose is thought to be low FODMAP.
Is hydroxypropyl a cellulose?
Hydroxypropylcellulose (HPC) is a cellulose ether in which hydroxyl groups on the cellulose backbone have been hydroxypropylated.
Is hydroxypropyl cellulose a carbohydrate?
Hydroxypropyl methylcellulose (HPMC) is a non-fermentable semi-synthetic dietary fibre, based on cellulose (Burdock, 2007), which is a carbohydrate consisting of anhydroglucose units (Reppas, Swidan, Tobey, Turowski, & Dressman, 2009).
What is Klucel high molecular weight (MW)?
In the formulation of modified release matrix systems, fine particle, medium to high molecular weight (MW) Klucel HPC is well known for its controlled release, compactability, and binder efficiency. Among the useful attributes of Klucel HPC are demonstrated robustness under different processing conditions,
What is the role of Klucel in solubility enhancement?
Low molecular weight grades such as Klucel EF and ELF can be used to enhance the solubility of low- soluble, Class II drugs. Klucel acts as a matrix in which drug molecules are immobilized and dispersed in a nanocrystralline or amorphous state.
What is the molecular weight of a hydroxypropylcellulose?
Klucel™ hydroxypropylcellulose EF and ELF have an approximate molecular weight of 80,000 and 60,000 Da, respectively, and hence undergo a faster erosion process, thus aiding in release of poorly soluble drugs dispersed or dissolved in the polymer matrix (25).
What is the role of Klucel in drug manufacturing?
Klucel acts as a matrix in which drug molecules are immobilized and dispersed in a nanocrystralline or amorphous state. Higher molecular weight grades (Klucel MF) can be used to make controlled-release tablets that are smaller, stronger, and less porous compared to those prepared via wet granulation.