What is neuroprotection in glaucoma treatment?
Neuroprotection in glaucoma refers to non-IOP-related interventions that can prevent or delay glaucomatous neurodegeneration, independently of IOP. The current article reviews and discusses the various strategies for neuroprotection in glaucoma to date.
Which glaucoma drops neuroprotective?
Brimonidine reduces aqueous humor production and stimulates aqueous humor outflow through the uveoscleral pathway. Preclinical studies have shown a neuroprotective effect on retinal ganglionic cells in animal models of optic nerve injury relevant to glaucoma [17].
Are neurotrophins cytokines?
Neurotrophins (NTs) such as nerve growth factor (NGF) as well as cytokines, for example, interleukin-6 (IL-6), are communicators between the nervous and immune systems. There is evidence for mutual interactions between NTs and cytokines.
Is CoQ10 good for glaucoma?
Overall, preliminary results in literature on CoQ10 are promising in glaucoma, as well as in other neurodegenerative conditions, thus endorsing the potential utility of CoQ10 in the treatment of glaucoma.
Why is brimonidine neuroprotective?
The literature confirms that brimonidine meets the following 3 criteria for neuroprotection: (1) receptors on its target tissues such as the optic nerve or retina, (2) adequate penetration into the vitreous and retina at pharmacologic levels, and (3) induction of intracellular changes that enhance neuronal resistance …
Can glasses help eye pressure?
Glaucoma glasses to reduce eye pressure Under the influence of this energy, drainage structure allows fluid to drain more easily from the eye, reducing internal eye pressure and decreasing the risk of optic nerve damage from glaucoma.
Is the hypothalamic neuropeptide a neuroprotective factor in glaucoma?
The hypothalamic neuropeptide, ciliary neurotrophic factor (CNTF), is a neuronal survival factor that may potentially confer neuroprotection in glaucoma.
What is neuroprotection in glaucoma?
The term “neuroprotection” refers to a therapeutic paradigm which is able to prevent glaucomatous neurodegeneration, or at least to slow down the progression of the RGC death [131]. Indeed, the possibility of counteracting some of the different complex pathways underlying the apoptotic cascade could represent the key to RGC protection [134,135].
What is the role of neuroprotective ligand in glaucoma pathogenesis?
This dual delivery of both the neuroprotective ligand and its receptor allows for the prolonged activation of ganglion cell survival pathways and may prove to be a reliable therapeutic approach to POAG in the planned Phase I/IIa trials. Aside from IOP, vascular dysregulation has also been suggested in glaucoma pathogenesis.
Is intraocular pressure a risk factor for glaucoma?
Glaucoma, a progressive optic neuropathy characterized by retinal ganglion cell degeneration and visual field loss, is a leading cause of irreversible blindness worldwide. Intraocular pressure (IOP) is currently the only modifiable risk factor for this disease. However, glaucomatous damage persists in almost 50% of patients, despite lowering IOP.