What does the 5-HTT gene do?
The 5-HTT gene has been associated with both depression and autism. The serotonin transporter protein (5-HTT/SLC6A4) transports the neurotransmitter serotonin from synapses to presynaptic neurons. It seems to be an important component in the physiological response to cocaine and amphetamines.
Is SERT a gene?
The serotonin transporter (SERT or 5-HTT) also known as the sodium-dependent serotonin transporter and solute carrier family 6 member 4 is a protein that in humans is encoded by the SLC6A4 gene.
Where is SLC6A4 located?
SLC6A4 is found in various cellular compartments such as cytosol, endosome, plasma membrane, and integral component of plasma membrane, integral component of postsynaptic membrane, integral component of presynaptic membrane, endomembrane system, neuron projection, and serotonergic synapse (Müller et al., 2006; Brenner …
How does 5-HTT gene affect depression?
We found strong evidence that a serotonin transporter promoter polymorphism (5-HTTLPR) moderates the relationship between stress and depression, with the less functional s allele associated with increased stress sensitivity.
What is a polymorphic zone?
A gene is said to be polymorphic if more than one allele occupies that gene’s locus within a population. Gene polymorphisms can occur in any region of the genome. The majority of polymorphisms are silent, meaning they do not alter the function or expression of a gene.
What is SERT expression?
In preclinical and clinical studies aging has been associated with a deteriorated response to antidepressant treatment. We hypothesize that such impairment is explained by an age-related decrease in brain serotonin transporter (SERT) expression associated with low testosterone (T) levels.
What chromosome is SLC6A4 on?
Linkage mapping of serotonin transporter protein gene SLC6A4 on chromosome 17.
Where is the serotonin transporter?
Serotonin transporters (5-HTT or SERT) and receptors (5-HT1–7) are located in the central, peripheral, and enteric nervous systems, and have been identified in several other peripheral tissues including bone.