Does febuxostat cause death?
Sudden cardiac death, the most common cause of CV death in both groups, occurred in 2.7% on febuxostat and 1.8% on allopurinol. The risk of CV death that occurred during treatment or within 30 days after discontinuation of treatment was higher among those on febuxostat than on allopurinol.
What is the brand name of febuxostat?
Febuxostat (Brand Name Uloric): Drug Safety Communication | Institute For Safe Medication Practices.
Can allopurinol be discontinued?
When used to treat high uric acid levels caused by treatments for leukemia, lymphoma, and other malignancies, it should be discontinued when the potential for overproduction of uric acid is no longer present. Occasionally may cause drowsiness. Affected people should not drive or operate machinery.
When is allopurinol contraindicated?
dehydration. chronic heart failure. liver problems. moderate to severe kidney impairment.
Does febuxostat affect the heart?
Compared with other SU-lowering treatments, febuxostat does not increase or decrease the risk of cardiovascular disease but may increase the risk of CVD death. More RCTs measuring cardiovascular safety as a primary outcome are needed to adequately evaluate the risk of CVD with febuxostat.
What happens if I stop taking febuxostat?
Once you are prescribed febuxostat it is very important that you do not stop taking it unless advised by your doctor or unless side effects develop. If febuxostat treatment is stopped there is a high risk that your gout may worsen. You should continue to take it even if you do not have symptoms.
Does febuxostat affect the liver?
No instances of acute liver failure or chronic liver injury have been reported due to febuxostat, but the clinical experience with this agent is limited.
What is the side effects of febuxostat?
Side Effects
- Arm, back, or jaw pain.
- black, tarry stools.
- bloody nose.
- chest pain or discomfort.
- cloudy urine.
- decreased frequency or amount of urine.
- diarrhea.
- difficult or labored breathing.
Is there a substitute for allopurinol?
Febuxostat, a novel nonpurine selective inhibitor of xanthine oxidase, is a potential alternative to allopurinol for patients with hyperuricemia and gout.
Can allopurinol cause depression?
Conclusion: Patients experiencing frequent gout attacks or attacks in multiple joints are likely to experience depressive symptoms, even when using allopurinol. Depression may influence medication adherence and participation in routine reviews, hence impacting adversely on gout management outcomes.
Does coffee interfere with allopurinol?
Over time, however, taking the drug gradually decreases the amount of uric acid to a point where attacks no longer occur. That’s why occasional coffee drinkers may have more gout attacks when taking allopurinol, while regular coffee drinkers may not.
What vitamins should not be taken with allopurinol?
Allopurinol can interact with ingredients in some foods and medications. For example, do not take vitamin C supplements or consume excessive amounts of vitamin C, as this can interact with allopurinol and lead to kidney stone formation.