How harmful is THF?
* Tetrahydrofuran can cause headache, nausea and dizziness. Very high exposure can cause unconsciousness and death. * Tetrahydrofuran may damage the liver and kidneys. * Tetrahydrofuran is a FLAMMABLE LIQUID and a DANGEROUS FIRE HAZARD.
What is tetrahydrofuran used for?
Tetrahydrofuran (THF) is commonly used as solvent, reaction medium, and starting material for various syntheses in the chemical industry, for example, for preparing adhesives, special paints, coatings, fibers, in the extraction of specific active substances, for recrystallization of certain compounds or as starting …
Where can tetrahydrofuran be found?
Coffea arabica
Tetrahydrofuran is a natural product found in Coffea arabica and Castanopsis cuspidata with data available. Oxolane is a cyclic ether that is butane in which one hydrogen from each methyl group is substituted by an oxygen. It has a role as a polar aprotic solvent.
Which of the following drug has tetrahydrofuran ring in the structure?
Chemical structure of annonacin, an acetogenin. Eribulin (brand name: Halaven), a commercial thf-containing anticancer drug.
How do you handle tetrahydrofuran?
THF must be stored in an air-impermeable container and placed in a dark area to prevent further promotion of the peroxide-forming reaction. Suitable fire control devices (such as fire extinguishers) must be available at locations where flammable or combustible liquids are stored.
Is DCM poisonous?
DCM poisoning, although rare, is fatal in most cases. The mechanism of toxicity of this substance is known, but the ability to recognize its clinical presentation and the ability to act quickly and effectively can be decisive in the success of treating the patient.
Why is it called tetrahydrofuran?
That’s right, it means four, for the four hydrogen atoms that have been added! Another important structural aspect of THF is that it’s a polar molecule.
Is tetrahydrofuran a functional group?
It’s characterized as a heterocyclic ether. Therefore, it has a ring structure with at least one of the atoms as something other than carbon (oxygen in this case), and an ether functional group.
What happens when tetrahydrofuran treated with HI explain with mechanism?
Tetrahydrofuran when treated with excess HI, gives 1, 4-diiodobutane.
Does tetrahydrofuran expire?
If tested, note the date it was tested on the bottle. Test open THF containers with peroxide test strips every 3 months. An opened container can be stored for a maximum of 6 months.
What is the freezing point of tetrahydrofuran?
-163.1°F (-108.4°C)Tetrahydrofuran / Melting point
What happens if you smell dichloromethane?
Inhalation – can cause coughing, wheezing and/or shortness of breath. Higher levels of dichloromethane inhalation can lead to headache, mental confusion, nausea, vomiting, dizziness and fatigue.