What are phospholipid binding proteins?
Phospholipid binding proteins, especially β2GP1 and Annexin V, form complexes with phospholipids, and have an important regulatory function in controlling the biological activity of these phospholipid surfaces (β2GP1, and, especially Annexin V, have an anticoagulant function).
What is phospholipid antibody?
Antiphospholipid (AN-te-fos-fo-LIP-id) syndrome is a condition in which the immune system mistakenly creates antibodies that attack tissues in the body. These antibodies can cause blood clots to form in arteries and veins. Blood clots can form in the legs, lungs and other organs, such as the kidneys and spleen.
What do antiphospholipid antibodies bind to?
Antiphospholipid antibodies are antibodies directed against phosphorus-fat components of your cell membranes called phospholipids, certain blood proteins that bind with phospholipids, and the complexes formed when proteins and phospholipids bind.
What is phospholipid antibody IGG?
Pathologic levels of autoantibodies reflect loss of tolerance and increased production of antibodies. These autoantibodies are called phospholipid or cardiolipin antibodies when they are detected by immunoassays that employ anionic phospholipids as substrates.
Is antiphospholipid antibody syndrome the same as lupus?
People with lupus may develop Antiphospholipid Syndrome (APS), a condition that can cause blood clots and other health problems. APS is sometimes called Antiphospholipid Antibody Syndrome.
Where do antiphospholipid antibodies come from?
These may be found in people with abnormal blood clots or autoimmune diseases. Your immune system usually creates antibodies in response to an infection or foreign invaders like bacteria. Antiphospholipid antibodies are usually made when your immune system mistakes part of your own body for a harmful substance.
What is an integral membrane protein examples?
IMPs include transporters, channels, receptors, enzymes, structural membrane-anchoring domains, proteins involved in accumulation and transduction of energy, and proteins responsible for cell adhesion. Examples of which are integrin, cadherin, insulin receptor, NCAM, selectin, glycophorin, rhodopsin, etc. Acronym: IMP.
Why are phospholipids important?
Phospholipids serve as a major structural component of most biological membranes, e.g. cell membrane. The phospholipids are vital to the function of the cell membrane. Being amphipathic, their presence creates an effective barrier preventing the entry of all molecules. Not all molecules would be able to enter the cell.