What are therapeutic nanoparticles?
Currently, the majority of FDA-approved therapeutic nanoparticles are developed as a re-formulation of chemotherapeutic drugs combinations with polymeric nanoparticles. The first nano-drug for cancer treatment was a PEGylated liposomal formulation of doxorubicin (Doxil®, Caelyx®).
What are Theranostic nanoparticles?
Theranostic nanoparticles are multifunctional nanosystems, which are well-designed for more specific and personalized disease management by combining diagnostic and therapeutic capabilities into one single biocompatible and biodegradable nanoparticle (1).
How is nanotechnology used in chemotherapy?
Nanotechnology can help to make cancer treatments safer and more precise. Specially designed nanoparticles deliver medicines like chemotherapy straight to the tumor. They don’t release the medicine until they reach it. This stops the drugs from damaging healthy tissues around the tumor.
What is nano surgery?
Nanosurgery is the term that refers to surgery that uses fast laser beams which are focused by an objective microscope lens to exert a controlled force to manipulate organelles and other subcellular structures.
Why nanoparticles are used in drug delivery?
Due to their small size and large surface area, drug nanoparticles show increase solubility and thus enhanced bioavailability, additional ability to cross the blood brain barrier (BBB), enter the pulmonary system and be absorbed through the tight junctions of endothelial cells of the skin (Kohane, 2007).
What are disadvantages of nanoparticles?
Nanoparticles can cause lung damage. Inhaled particulate matter may get deposited throughout the human respiratory tract and then in the lungs. The characteristics of nanoparticles that are relevant for health effects are size, chemical composition, and shape.
How are nanoparticles cleared from the body?
For nanoparticles that do not biodegrade in vivo into biologically benign components, the only other major route of excretion from the human body is through the liver, into bile, and into feces. The problems with liver excretion for nanoparticles are three-fold.
What is Theranostic treatment?
Theranostics is the term used to describe the combination of using one radioactive drug to identify (diagnose) and a second radioactive drug to deliver therapy to treat the main tumor and any metastatic tumors.
What is theranostics Wikipedia?
Theranostics. Theranostics is a personalised approach to treating cancer, using similar molecules for both imaging (diagnosis) and therapy. The word “theranostics” is derived from the combination of the words “therapeutics” and “diagnostics”.