What does BH3-only protein do?

What does BH3-only protein do?

BH3-only proteins monitor many cellular processes and transmit both intrinsic and extrinsic death signals to the multi-region Bcl-2 family proteins at the MOM. BH3-only proteins inhibit the anti-apoptotic proteins and activate the pro-apoptotic proteins to cause mitochondrial outer membrane permeabilization (MOMP) [2].

Is Puma a BH3-only protein?

The BH3-only protein Puma is both necessary and sufficient for neuronal apoptosis induced by DNA damage in sympathetic neurons. J Neurochem. 2006 Mar;96(5):1213-26.

Is p53 a BH3 protein?

However, BH3-only protein, p53 upregulated modulator of apoptosis (Puma) is induced by p53-dependent and p53- independent apoptotic stimuli in several cancer cell lines.

How BH3-only proteins are regulated?

The BH3-only proteins activate apoptosis by binding and neutralizing the pro-survival proteins, allowing Bax/Bak to homo-oligomerize and permeabilize the mitochondria. This displacement model does not require any interaction between the BH3-only proteins and Bax/Bak (Willis et al., 2007).

What does BH3 and THF do?

Borane–tetrahydrofuran is a dipolar bond charge-transfer complex composed of borane and tetrahydrofuran (THF). These solutions are used for reductions and hydroboration, reactions that are useful in synthesis of organic compounds.

What is BH3?

BH3 could refer to. The molecule borane, which has a chemical formula of BH3.

Where are BH3-only proteins located?

The BH3 domain of BH3-only proteins inserts in the hydrophobic groove formed by the BH1, BH2 and BH3 domains at the surface of the pro-survival molecules.

What can BH3 reduce?

Borane Complexes: BH3•L Borane is commonly used for the reduction of carboxylic acids in the presence of esters, lactones, amides, halides and other functional groups. In addition, borane rapidly reduces aldehydes, ketones, and alkenes.