What does Pvns look like on MRI?
MRI. MRI typically shows mass-like synovial proliferation with lobulated margins. This may be extensive in the diffuse form or limited to a well-defined single nodule in the localized form 9 with low signal intensity due to hemosiderin deposition.
Does Pvns show on xray?
PVNS in the knee typically manifests as a non-specific joint effusion on radiographs, although occasionally the fluid may appear dense, a finding suggestive of hemorrhagic effusion.
Is Pvns an autoimmune disease?
Introduction. Pigmented villonodular synovitis is a rare disease of unknown etiology mostly affecting the knee and foot. Until now an association with autoimmune diseases has not been reported.
What is localized pigmented villonodular synovitis?
Pigmented villonodular synovitis (PVNS) is a joint problem that usually affects the hip or knee. It also can occur in the shoulder, ankle, elbow, hand or foot. When you have PVNS, the lining of a joint becomes swollen and grows. This growth harms the bone around the joint.
Can PVNS be malignant?
Malignant pigmented villonodular synovitis (PVNS) (or malignant giant cell tumor of tendon sheath (GCTTS) is an extremely rare condition defined as a malignant lesion occurring with concomitant or previously documented PVNS at the same site.
Is PVNS rare?
PVNS is a rare condition. It affects only about 2 out of every 1 million people .
How serious is PVNS?
However, PVNS is a progressive disease. It slowly worsens and can lead to bone damage and arthritis. PVNS usually affects the knee, although it can affect other joints as well. In most cases, surgery is needed to remove the damaged joint lining and the mass.
Is PVNS life threatening?
PVNS has been described as a growth or a tumor in the lining of the joint. While it is accurately labeled as a tumor, it is not cancer and it is not typically life-threatening.
Is PVNS a tumor?
Pigmented villonodular synovitis (PVNS) is a condition that causes the synovium—the thin layer of tissue that lines the joints and tendons—to thicken and overgrow. The mass or tumor that results from this overgrowth is not cancerous and does not spread (metastasize) to other areas of the body.
Is PVNS a Tumour?
Pigmented villonodular synovitis (PVNS) is a type of benign (non-cancerous) tumor that arises from the soft connective tissue of joints. Any joint can be affected, although the tumor is most commonly found in the knee or hip joint. Although it can be painful, PVNS usually does not spread.
What does Localized PVNS of the knee mean?
Localized PVNS is an unusual presentation of the disease, generally consisting of a nodular lesion protruding into the articular cavity. Localized PVNS of the knee can mimic other joint disorders which may pose a challenge for a correct diagnosis.
Which imaging studies are used to diagnose pigmented villonodular synovitis (PVNS)?
Barile A, Sabatini M, Iannessi F et al. Pigmented Villonodular Synovitis (PVNS) of the Knee Joint: Magnetic Resonance Imaging (MRI) Using Standard and Dynamic Paramagnetic Contrast Media. Report of 52 Cases Surgically and Histologically Controlled.
What is the pathophysiology of PVNS?
Traditionally, most authors believed that PVNS is a result of reactive chronic inflammation but the capability of these lesions for autonomous growth, the malignant transformation potential, and recently found constant cytogenetic aberrations in most cases are suggesting that PVNS has a neoplastic origin 2.
What is the prevalence of PVNS?
PVNS occurs predominantly in the early to middle age (2 nd to 5 th decades) 1,2 . In intra-articular disease, there is no gender predilection, whereas extra-articular disease has a slight female predominance. Presentation is usually with joint swelling, pain and occasionally joint dysfunction.