What drugs are PARP inhibitors?
A PARP inhibitor is a type of prescription drug that helps treat certain types of cancer. It blocks the PARP enzymes in cells. PARP enzymes help repair DNA damage….There are four main PARP inhibitors:
- olaparib (Lynparza)
- niraparib (Zejula)
- rucaparib (Rubraca)
- talazoparib (Talzenna)
What is the effect of p53?
A gene that makes a protein that is found inside the nucleus of cells and plays a key role in controlling cell division and cell death. Mutations (changes) in the p53 gene may cause cancer cells to grow and spread in the body.
What is PARP 1 inhibitor?
PARP1 inhibitors are promising antitumor agents, since they act as chemo- and radiosensitizers in the conventional therapy of malignant tumors. Furthermore, PARP1 inhibitors can be used as independent, effective drugs against tumors with broken DNA repair mechanisms.
What is p53 therapy?
Another experimental cancer therapy in development involves “patching” mutated p53 genes in cells so they can function normally again. Doctors could potentially use this medicine to treat cancer and prevent it by repairing defective p53 genes before cells have the chance to become cancerous.
Is p53 an inhibiting protein?
p53 is a nuclear transcription factor with a pro-apoptotic function. Since over 50% of human cancers carry loss of function mutations in p53 gene, p53 has been considered to be one of the classical type tumor suppressors. Mutant p53 acts as the dominant-negative inhibitor toward wild-type p53.
How do PARP inhibitors work with BRCA?
PARP inhibitors, used to treat patients with cancer of the breast, ovaries, prostate and pancreas, work by inducing persistent DNA gaps in tumor cells with BRCA1 and BRCA2 mutations.
Is Zytiga a PARP inhibitor?
PARP + Zytiga Improves Outcomes. Adding the PARP inhibitor Zejula to the anti-androgen drug Zytiga may be a new first-line treatment for patients with metastatic castration-resistant prostate cancer (mCRPC) with homologous recombination deficiency.