What drugs does acetylcysteine interact with?
Acetylcysteine has no known serious interactions with other drugs….Mild interactions of acetylcysteine include:
- azithromycin.
- bazedoxifene/conjugated estrogens.
- chloramphenicol.
- clarithromycin.
- demeclocycline.
- dichlorphenamide.
- doxycycline.
- erythromycin base.
Can mucomyst be given IV?
The newer 48-hour protocol consists of a loading dose of 140 mg/kg followed by 12 doses of 70 mg/kg every 4 hours. As previously noted, although not approved by the FDA, oral acetylcysteine has effectively been used intravenously in the United States.
How is acetylcysteine administered?
Acetylcysteine is administered orally, intravenously, or by inhalation. Once in the systemic circulation, 66% to 87% of the drug is bound to plasma proteins. Any acetylcysteine that is absorbed systemically is deacetylated by the liver and intracellularly in most tissues to cysteine and disulfides.
How do you dilute Mucomyst?
Preparation of Acetylcysteine Solution (n-acetyl-l-cysteine) for Oral Administration: Oral administration requires dilution of the 20% solution with diet cola, or other diet soft drinks, to a final concentration of 5% (See Dosage Guide and Preparation table).
Why is acetylcysteine given IV?
Acetylcysteine injection is used to help prevent or lessen liver damage caused by an overdose of acetaminophen.
Does mucomyst have to be given with a bronchodilator?
Acetylcysteine is not a bronchodilator because it does not relax your airway. Most people who take acetylcysteine will also be need to take a bronchodilator like albuterol or ipratropium.
What is acetylcysteine IV used for?
Summary: I.V. acetylcysteine is most often used as an antidote for acetaminophen overdose due to its ability to increase levels of glutathione; however, it is also used to treat NAI-ALF and severe alcoholic hepatitis and to prevent CIN.
How is Mucomyst administered?
Acetylcysteine may be introduced directly into a particular segment of the bronchopulmonary tree by inserting (under local anesthesia and direct vision) a small plastic catheter into the trachea. Two to 5 mL of the 20% solution may then be instilled by means of a syringe connected to the catheter.
What is the antidote for Mucomyst?
Acetylcysteine, administered orally, is indicated as an antidote to prevent or lessen hepatic injury which may occur following the ingestion of a potentially hepatotoxic quantity of acetaminophen.
How do you administer Mucomyst?
The medicine is inhaled through a face mask, mouthpiece, or tracheostomy. The 10 or 20% solution may be used for inhalation as a heavy mist in a tent or croupette. Sometimes the 10 or 20% solution is placed directly into the trachea or through a catheter into the trachea for certain conditions.
How do you administer Mucomyst orally?
If you are taking this medication by mouth, take it as directed by your doctor. The solution is usually mixed with another liquid (such as cola) to decrease nausea and vomiting. Drink the medication within 1 hour of mixing.
What is the dose of mucomyst?
Mucomyst Dosage and Administration. General. Mucomyst is available in rubber stoppered glass vials containing 4, 10, or 30 mL. The 20% solution may be diluted to a lesser concentration with either Sodium Chloride for Injection, Sodium Chloride for Inhalation, Sterile Water for Injection, or Sterile Water for Inhalation.
Does mucomyst contain an antimicrobial agent?
Mucomyst does not contain an antimicrobial agent, and care must be taken to minimize contamination of the sterile solution. If only a portion of the solution in a vial is used, store the remainder in a refrigerator and use for inhalation only within 96 hours. NEBULIZATION—FACE MASK, MOUTH PIECE, TRACHEOSTOMY
When is mucomyst (acetylcysteine) administered for acetaminophen toxicity?
Regardless of the quantity of acetaminophen reported to have been ingested, administer Mucomyst (acetylcysteine) immediately if 24 hours or less have elapsed from the reported time of ingestion of an overdose of acetaminophen. Do not await results of assays for acetaminophen level before initiating treatment with Mucomyst.
Can mucomyst 10% be used undiluted?
General. The 10% solution may be used undiluted. Mucomyst does not contain an antimicrobial agent, and care must be taken to minimize contamination of the sterile solution. If only a portion of the solution in a vial is used, store the remainder in a refrigerator and use for inhalation only within 96 hours.