What is evaluation of suppositories?
A method is described for the evaluation of suppositories by allowing the drug to be released from the base and dissolved into normal saline solution at body temperature. The rate of release of the theophylline (as aminophylline) was compared for twenty-five suppository base formulas.
What affects the stability of suppositories?
Common factors that affect this stability include temperature, light, pH, oxidation and enzymatic degradation. Special considerations are also required when dealing with chiral molecules, deuterated internal standards and large biomolecules.
What excipients are used in suppositories?
The hydrophilic class of suppositories include excipients that dissolve in the presence of water. These include primarily glycerin, gelatin and water soluble polymers such as PEG. Suppositories based on glycerin are most known for use in the treatment of constipation.
What can cause a suppository to be brittle?
Liquids may occupy too much volume to be easily incorporated, and the vehicles may not be compatible with selected suppository bases. Tablets and capsules may contain excessive powder, which could produce suppositories that are too brittle.
What are the 3 methods used in the preparation of suppositories?
Preparation of suppository
- PREPARATION OF SUPPOSITORIES PREPARED BY SAIF ULLAH KHAN.
- TYPES OF SUPPOSITORY Suppositories are prepared by three methods:- • Molding • Compression • Hand rolling and shaping.
What are organoleptic additives?
Organoleptic additives promote appearance and palatability of pharmaceutical dosage forms. If the product does not have acceptable colour, flavor and taste the patient would try to avoid using it.
What are three factors that affect stability?
low centre of mass. the lower the centre of mass, the higher the stability.
What is the displacement value?
Displacement Value can be defined as the. volume of drug that displaces 1 gram of suppository base. The most commonly used suppository base is Coca Butter or Theobroma oil. Traditionally suppositories are prepared using suppositories molds which can generally hold 1 gram or 2 gram of base.
What are bases used to prepare suppositories?
The USP lists the following as usual suppository bases: cocoa butter, cocoa butter substitutes (primarily vegetable oils), glycerinated gelatin, hydrogenated vegetable oils, mixtures of PEGs of various molecular weights, and fatty acid esters of polyethylene glycol.
What is the best suppository base?
Suppositories for Systemic Administration For systemic effect, we recommend using either PCCA Base A or PCCA MBK. Depending on the therapeutic use, the route of administration may be vaginal or rectal.
How to test for in vitro dissolution of suppositories?
19. DISSOLUTION TEST By using different types of apparatus such as wire mesh basket, or dialysis tubing is used to test for in vitro release from suppositories 20. Two types of apparatus are avaliable for testing the dissolution rate.
How are hydrophilic suppositories tested?
Hydrophilic suppositories are tested using stationary basket. 21. STABILITY TESTING Cocoa butter suppositories on storage, “bloom”; i.e., they form a white powdery deposit on the surface. This can be avoided by storing the suppositories at uniform cool temperatures and by wrapping them in foils.
How do you test the hardness of a suppository?
BREAKING TEST ( HARDNESS) The breaking test is designed as a method for measuring the brittleness of suppository. 1-The suppository is placed in the instrument. 2- Add 600 g; leave it for one min. (use a stop watch). 3- If not broken, add 200 g every one min. until the suppository is broken. 19.
What is the melting test of suppository?
The melting test consists of placing a suppos-itory on the surface of water thermostaticallycontrolled at 37◦C and verifying the completemelting of the suppository in a few minutes. Thisisnotsomuchameasurementasanevaluation.