What is product of an aldol addition reaction?
The aldol addition in a nutshell is when the newly formed enolate reacts with another aldehyde or ketone to form a new carbon-carbon bond and thus a larger organic compound. Kind of like building railroad tracks! The general form of the aldol addition is enolate + aldehyde or ketone = aldol product.
Which compound gives aldol reaction?
In its usual form, it involves the nucleophilic addition of a ketone enolate to an aldehyde to form a β-hydroxy ketone, or “aldol” (aldehyde + alcohol), a structural unit found in many naturally occurring molecules and pharmaceuticals….
| Aldol condensation | |
|---|---|
| RSC ontology ID | RXNO:0000017 |
What is a crossed aldol reaction?
Crossed aldol condensation is a variation of aldol condensation in which two dissimilar carbonyl compounds (each containing alpha hydrogens) undergo the condensation reaction together. In such reactions, up to four different products may be formed.
What happens in aldol condensation?
In an aldol condensation, an enolate ion reacts with a carbonyl compound in the presence of acid/base catalyst to form a β-hydroxy aldehyde or β-hydroxy ketone, followed by dehydration to give a conjugated enone. It is a useful carbon-carbon bond-forming reaction.
What kinds of compounds can be prepared by an aldol addition reaction?
More generally, an aldol addition is characterized as a nucleophilic addition to an aldehyde, ketone, or imine electrophile where the nucleophile is the a-carbon in an aldehyde, ketone, imine, ester, or thioester.
What is the meaning of aldol addition?
Aldol Addition. Aldol Reaction. ‘Aldol’ is an abbreviation of aldehyde and alcohol. When the enolate of an aldehyde or a ketone reacts at the α-carbon with the carbonyl of another molecule under basic or acidic conditions to obtain β-hydroxy aldehyde or ketone, this reaction is called Aldol Reaction.
How many products can be obtained from a mixed aldol reaction?
Up to four products are possible (two “self-addition” and two “crossed-addition” products). Mixed aldol reactions between an aldehyde with no α-hydrogens and a ketone generally give good yields of a single product. • Only enolate possible is from the ketone • Aldehydes are better electrophiles than ketones.
Why is proton transfer avoided with lithium enolates at low temperatures?
Proton transfer is avoided with lithium enolates at low temperatures in ethereal solvents, so that addition of a second carbonyl partner (ketone or aldehyde) will produce the desired aldol product. V. Maya, M. Raj, V. K. Singh, Org. Lett., 2007 , 9, 2593-2595.