What is the role of Factor XIII in coagulation?
Factor XIII is the last step of the clotting cascade, and it functions to stabilize the clot. Mutations of the F13A1 or the F13b gene result in deficient levels of functional factor XIII, which causes blood clots to be weak and unstable resulting in fast breakdown.
What is f13a?
Entrez Gene Summary for F13A1 Gene This gene encodes the coagulation factor XIII A subunit. Coagulation factor XIII is the last zymogen to become activated in the blood coagulation cascade. Plasma factor XIII is a heterotetramer composed of 2 A subunits and 2 B subunits.
What is factor XIII name?
FACTOR XIII (Fibrin Stabilizing Factor) DEFICIENCY Factor XIII (FXIII), or fibrin stabilizing factor, deficiency was first reported in the literature in 1960.
Where is factor XIII found?
The factor XIII A chain gene is found on chromosome 6. Circulation of plasma factor XIII occurs in association with its substrate, fibrinogen.
Is Factor 13 deficiency common?
Inherited factor XIII deficiency affects 1 to 3 per million people worldwide. Researchers suspect that mild factor XIII deficiency, including the acquired form of the disorder, is underdiagnosed because many affected people never have a major episode of abnormal bleeding that would lead to a diagnosis.
How common is factor XIII deficiency?
Where is factor 13 found?
Monocytes/macrophages can synthesize factor XIII, while megakaryocytes are probably responsible for synthesizing the factor XIII found in platelets. The primary site for the synthesis of subunit A in plasma factor XIII seems to exist in cells that originate in the marrow. Synthesis of the B subunit occurs in the liver.
Is factor XIII produced in the liver?
Factor XIII-B is primarily produced in the liver (Wolpl et al., 1987). Factor XIII is activated by thrombin cleavage of the A-subunits.
What is F13A1 coagulation factor XIII?
74145 – Gene ResultF13a1 coagulation factor XIII, A1 subunit [ (house mouse)] This gene encodes subunit A of the coagulation factor XIII that catalyzes the final step of the blood coagulation pathway.
What is factor XIII made of?
Factor XIII in the bloodstream is made of two A subunits (produced from the F13A1 gene) and two B subunits (produced from the F13B gene). When a new blood clot forms, the A and B subunits separate from one another, and the A subunit is cut (cleaved) to produce the active form of factor XIII (factor XIIIa).
Is factor XIII a associated with deep venous thrombosis?
A common polymorphism in the gene for factor XIII A subunit (F13A1 V34L) has been associated with a decreased risk for coronary artery disease, cerebrovascular disease, and deep venous thrombosis. analysis of the expression, localization and activity of TG2 and FXIIIA in mineralizing tissues [review]
What is the F13A1 gene?
Learn more The F13A1 gene provides instructions for making one part, the A subunit, of a protein called factor XIII. This protein is part of a group of related proteins called coagulation factors that are essential for normal blood clotting.