What is totect used for?
Dexrazoxane injection (Totect, Zinecard) is used to prevent or decrease thickening of the heart muscles caused by doxorubicin in women who are taking the medication to treat breast cancer that has spread to other parts of the body.
How to administer dexrazoxane?
Dexrazoxane should be administered as an iv infusion over 1 to 2 hours in a large caliber vein in an extremity/area other than the one affected by the extravasation.
How to prepare dexrazoxane?
Preparation: Dexrazoxane must be reconstituted with 0.167 Molar (M/6) Sodium Lactate Injection USP to give a concentration of 10 mg dexrazoxane for each mL of sodium lactate. The reconstituted solution should be given by slow I.V. push or rapid drip intravenous infusion from a bag.
How does Mesna work?
Mesna is an organosulfur compound. It works by altering the breakdown products of cyclophosphamide and ifosfamide found in the urine making them less toxic.
What are the side effects of vincristine?
Vincristine may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:
- nausea.
- vomiting.
- sores in the mouth and throat.
- loss of appetite or weight.
- stomach pain.
- diarrhea.
- headache.
- hair loss.
How does vincristine work in the body?
How it works. Vincristine is a chemotherapy drug that belongs to a group of drugs called vinca alkaloids. Vincristine works by stopping the cancer cells from separating into 2 new cells. So, it stops the growth of the cancer.
Is dexrazoxane a chemo drug?
Presently, dexrazoxane is licensed in many parts of the world for two different indications: prevention of cardiotoxicity from anthracycline-based chemotherapy, and prevention of tissue injuries after extravasation of anthracyclines.
When do you take dexrazoxane?
Dexrazoxane is used to reduce the incidence and severity of heart problems associated with the chemotherapy agent doxorubicin in women being treated for metastatic breast cancer. It is only used for women who have received a high cumulative dose of doxorubicin and who would benefit from continued therapy.
Who makes dexrazoxane?
West-Ward’s Dexrazoxane for Injection is indicated for reducing the incidence and severity of cardiomyopathy associated with doxorubicin administration in certain women with metastatic breast cancer who have received a cumulative doxorubicin dose of 300 mg/m2 and who will continue to receive doxorubicin therapy to …
How do I administer Zinecard?
Administer ZINECARD Injection via intravenous infusion over 15 minutes. DO NOT ADMINISTER VIA AN INTRAVENOUS PUSH. The recommended dosage ratio of ZINECARD to doxorubicin is 10:1 (e.g., 500 mg/m2 ZINECARD to 50 mg/m2 doxorubicin).
What is Totect used for?
Totect (dexrazoxane for injection) is a sterile, pyrogen-free lyophilized powder intended for intravenous (IV) administration. Each Totect carton contains 1 single dose vial of Totect (dexrazoxane Totect (dexrazoxane for injection) is a sterile, pyrogen-free lyophilized powder intended for intravenous (IV) administration.
What is Totect made of?
Totect® (dexrazoxane for injection) is a sterile, pyrogen-free lyophilized powder intended for intravenous (IV) administration. Each Totect® carton contains 1 single dose vial of Totect® (dexrazoxane for injection) 500 mg.
How do I take Totect?
Totect is given to you by your healthcare provider into your vein (intravenous or IV infusion). To treat anthracycline chemotherapy leaks, you will receive Totect over 1 to 2 hours each day for three days. To reduce the occurrence and severity of heart muscle problems, you will receive Totect over 15 minutes before your doxorubicin treatment.
How many doses of Totect are in a carton?
Each Totect carton contains 1 single dose vial of Totect (dexrazoxane Totect (dexrazoxane for injection) is a sterile, pyrogen-free lyophilized powder intended for intravenous (IV) administration. Each Totect carton contains 1 single dose vial of Totect (dexrazoxane for injection) 500 mg.