What is trifluoroacetic acid used for?
Trifluoroacetic acid has been used as the reagent of choice for the removal of nitrogen and oxygen protecting groups by solvolysis under aqueous or anhydrous conditions.
How to store trifluoroacetic acid?
TFA is a moisture-sensitive liquid. It may irritate eyes, skin, and/or the respiratory system. Store in a brown bottle or amber ampul at room temperature, in a dry, well ventilated area away from ignition sources. Use only in a well ventilated area and keep away from ignition sources.
What is the pKa of trifluoroacetic acid?
0.0
Ionization Constants of Heteroatom Organic Acids
| Common Name | Formula | pKa |
|---|---|---|
| benzenesulfonic acid | C6H5SO3H | ca. -2.5 |
| methanesulfonic acid | CH3SO3H | ca. -2.0 |
| trifluoroacetic acid | CF3CO2H | 0.0 |
| picric acid | (O2N)3C6H2OH | 0.3 |
Is trifluoroacetic acid toxic?
* Trifluoroacetic Acid is a CORROSIVE CHEMICAL and contact can severely irritate and burn the skin and eyes with possible eye damage. * Breathing Trifluoroacetic Acid can irritate the nose, throat and lungs causing coughing, wheezing and/or shortness of breath.
Is trifluoroacetic acid a Lewis acid?
Trifluoroacetic acid (TFA), 500 ml | (Lewis) Acids | Synthesis Reagents | Organic & Bioorganic Chemicals | Chemikalien | Carl Roth – International.
What is the boiling point of trifluoroacetic acid?
162.3°F (72.4°C)Trifluoroacetic acid / Boiling point
Is TFA toxic?
TFA is harmful when inhaled, causes severe skin burns and is toxic for aquatic organisms even at low concentrations. TFA’s reaction with bases and metals, especially light metals, is strongly exothermic. The reaction with lithium aluminium hydride (LAH) results in an explosion.
What is the formula of trifluoroacetic acid?
C2HF3O2Trifluoroacetic acid / Formula
Trifluoroacetic acid (TFA) is an organofluorine compound with the chemical formula CF3CO2H. It is a structural analogue of acetic acid with all three of the acetyl group’s hydrogen atoms replaced by fluorine atoms and is a colorless liquid with a vinegar-like odor.
What is molarity of trifluoroacetic acid?
1.489 g/mL
1.489 g/mL at 20 °C (lit.)
Is trifluoroacetic acid flammable?
Trifluoroacetic Acid itself does not burn. * POISONOUS GASES ARE PRODUCED IN FIRE, including Hydrogen Fluoride. * Use water spray to keep fire-exposed containers cool. * Trifluoroacetic Acid may ignite combustibles (wood, paper and oil).
Why is trifluoroacetic acid a strong acid?
TFA is a stronger acid than acetic acid, having an acid ionisation constant, Ka, that is approximately 34,000 times higher, as the highly electronegative fluorine atoms and consequent electron-withdrawing nature of the trifluoromethyl group weakens the oxygen-hydrogen bond (allowing for greater acidity) and stabilises …